Alison Marsden Presents…
Simulation-based Treatment Planning In Pediatric Cardiology
Simulation-based treatment planning in pediatric cardiology
Hemodynamics plays an essential role in the progression and treatment of cardiovascular disease. This is particularly true in pediatric cardiology, due to the wide variation in anatomy observed in congenital heart disease patients. While medical imaging provides increasingly detailed anatomical information, clinicians currently have limited knowledge of important fluid mechanical parameters. Treatment decisions are therefore often made using anatomical information alone, despite the known links between fluid mechanics and disease progression. Patient-specific simulations now offer the means to provide this missing information, and, more importantly, to perform in-silico testing of new surgical designs at no risk to the patient. In this talk, we will outline the current state of the art in methods for cardiovascular blood flow simulation and virtual surgery. We will then present new methodology for coupling optimization with simulation and uncertainty quantification to customize treatments for individual patients. We will present two examples in pediatric cardiology that illustrate the potential impact of these tools in the clinical setting: a novel Y-graft for the Fontan surgery, and simulations of flow in coronary artery aneurysms in patients with Kawasaki disease.
Alison Marsden is currently an assistant professor in the Mechanical and Aerospace Engineering department at UCSD. She graduated with a bachelor's degree in mechanical engineering from Princeton University in 1998, a PhD in mechanical engineering from Stanford in 2005, and did postdoctoral work at Stanford University in bioengineering and pediatric cardiology from 2005-07. She has been the recipient of an American Heart Association postdoctoral fellowship, an AHA beginning grant in aid award, a Burroughs Wellcome Fund Career Award at the Scientific Interface, an NSF CAREER award, and is a member of an international Leducq Foundation Network of Excellence involving clinicians and engineers. Her work focuses on the application of optimization to fluid mechanics with particular emphasis on cardiovascular surgery and congenital heart disease.